New evidence-based publications from the Agency for Healthcare Research and Quality (AHRQ) can help clinicians, patients and their families make informed decisions about treating major depression in adults.

One publication entitled “Nonpharmacological Versus Pharmacological Treatment for Patients with Major Depressive Disorder: Current State of the Evidence” is a clinician publication based on an AHRQ systematic review that found cognitive behavioral therapy is as effective as second-generation antidepressants in relieving symptoms of mild to severe major depressive disorder. Second-generation antidepressants generally lead to a higher risk of adverse events (including nausea, vomiting, diarrhea, fatigue, headache, insomnia and weight gain) when compared with behavioral therapy.

A plain-language companion publication, “Comparing Talk Therapy and Other Depression Treatments with Antidepressant Medicines – A Review of the Research for Adults,” is available for consumers. It can be used as a decision-making tool by RN case managers and the healthcare team to help patients and their families make informed decisions regarding depression treatment.